Toxic stress to the immune system through Allergies, Sinusitis and chronic immune system activation and inflammation
(a) Test for allergies to food
(b) Test for allergies to chemicals
(c) Test for allergies to any substance
Scientific and Medical Evidence - Listing of Research conducted worldwide section :
Skin rashes, acne and allergies worsen after the onset of CFS
Toxins and hazards, Heavy Metals, Organophosphates
P is elevated in ME patients
Increased risk of Cancer
Increased oxidative stress
Genetic markers .
Scientific Findings in Primer for International Consensus Criteria (2012)
CFS sufferers develop allergies and sinus inflammation or suffer an intensification of
such conditions after getting ME. Chronic allergies and sinus infections and inflammations over several years can lead to chronic immune system activation and resultant weakening. The cytokine shift from TH1 to TH2 in ME will worsen inflammation throughout the body, and any pre-existing allergies or sinus problems. In addition, undigested foods and toxins in the bloodstream will trigger immune system activation and inflammation.
Tests on 285 ME patients and 200 controls in 2013 by Hornig et al. in New York show that there are significant increases in Eosinophils and chronic allergic or inflammatory responses to some agent in those ME patients who have the illness for 3 years or less. (Preliminary findings of Hornig et al., September 2013). Dr. Paul Cheney, Dr. De Meirleir and Dr. Peterson are now using tests for mycotoxins as part of their diagnostics protocol for ME / CFS.
- If you suffer from Sinus problems or Sinusitis get an Ear, Nose and Throat doctor to take a biopsy of your inflamed sinus tissues. And test for molds, mycobacteria and mycotoxins, bacteria and viruses. In most cases mold and mycotoxins have been found to be the cause.
- Go to an Allergist and test for the following:
- Allergies to certain foods and drinks. Gluten Intolerance, Lactose Intolerance, and Coeliac disease.
- Allergies to household chemcials formaldehyde on furniture and upholstery
- Allergies to chemicals used in te workplace
- Allergies to dust in your bedroom or house
- Allergies to carpets. Carpets typically have 100 - 200 chemicals, some of which are toxic to humans. A cause of Allergies and neurotoxicity in some people.
- Allergies to moulds in your home. Moulds such as black mould are common on the walls of many houses and apartments in Nothern Europe and North America
- Allergies to pollen. This is usually predominant in Spring and Summer months
- Allergies from animal hairs
- Allergies resulting from car pollution, gas burners, oil burners in home or at work
- Allergies resulting from poor ventilation at home or in the workplace
- Comprehensive Food Allergy Profile test
- Test for Multiple Chemical
Sensitivity Syndrome and levels of Paraoxonase (PON) in blood
Check with allergists / consultants at your regional hospital or
top state hospital or private labs to see if they do these special
tests. If not, then the following labs can carry out these special
Laboratory: Comprehensive Food Allergy test http://www.gdx.net/uk/product/10
Metametrix labs http://www.metametrix.com/test-menu/profiles/categorized
Melissa Test http://www.melisa.org/
European Laboratory of Nutrients, the Netherlands http://www.europeanlaboratory.nl/
Fitzwilliam FoodTest clinic, Dublin http://www.fitzwilliamfoodtest.com/
Darina Joyce Clinic, Galway http://www.darinajoyce.com/index.html
- Test for Elevated Eosinophil levels in ME patients who have illness for 3 years or less. (Preliminary findings of Hornig et al., September 2013)
- Lectin intolerance can disrupt the immune system and other body systems. Get tested for Lectin intolerance.
Test Histamine levels
High histamine levels in the intestines can be caused by bad bacteria or intestinal dysbiosis or ingesting foods which raise histamine levels. Also impaired serum diamine oxidase (DAO) activity can lead to high histamine levels in the gut and the body. Histamine can increase inflammation in the gut and throughout the entire body, reduce digestion and absorption, and adversely affect the immune system and worsen the symptoms of ME. High histamine levels have been found in ME patients. It is a good indicator of intestinal dysbiosis.
- Test serum diamine oxidase (DAO) activity
- Test stool for histamine levels
- Test intestines for histamine levels
- Does the patient ingest foods and drinks with high histamine levels. High histamine levels in fish, cheese, hard cured sausages, sauerkraut, pickled cabbage, fermented foods, and alcoholic beverages
- Does the patient take medical drugs or foods which impair diamine oxidase (DAO) activity in the gut
- Does the patient have too much inflammation in the body - allergies, sinusitis, hives, eczema, inflammatory cytokines, etc. ?
- Serum diamine oxidase (DAO) activity as a diagnostic test for histamine intolerance. Ema Music.
Mira Silar, Peter Korosec, Mitja Kosnik, Matija Rijavec. Clinical and Translational Allergy
- Serum diamine oxidase activity as a diagnostic test for histamine intolerance.
Mušič E, Korošec P, Šilar M, Adamič K, Košnik M, Rijavec M. Wien Klin Wochenschr. 2013 May;125(9-10):239-43.
Histamine and histamine intolerance. Laura Maintz and
Natalija Novak. Am J Clin Nutr May 2007 vol. 85 no. 5 1185-1196
Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches.
Wantke F1, Götz M, Jarisch R. Clin Exp Allergy. 1993 Dec;23(12):982-5.
- Identification of a proton-chloride antiporter (EriC) by Himar1 transposon mutagenesis in Lactobacillus reuteri and its role in histamine production.
Hemarajata P, Spinler JK, Balderas MA, Versalovic J.
- Lactobacillus reuteri-specific immunoregulatory gene rsiR modulates histamine production and immunomodulation by Lactobacillus reuteri. Hemarajata P, Gao C, Pflughoeft KJ, Thomas CM, Saulnier DM, Spinler JK, Versalovic J.
- Effect of chemico-physical parameters on the histidine decarboxylase (HdcA) enzymatic activity in Streptococcus thermophilus PRI60.
Tabanelli G, Torriani S, Rossi F, Rizzotti L, Gardini F.
- Isolation and characterization of histamine-producing bacteria from fermented fish products. Moon JS, Kim SY, Cho KJ, Yang SJ, Yoon GM, Eom HJ, Han NS.
- Tyrosine- and histidine-decarboxylase positive lactic acid bacteria and enterococci in dry fermented sausages. Komprda T, Sládková P, Petirová E, Dohnal V, Burdychová R.
- PubMed articles on histamine and gut bacteria
- Test for mast cell dysfunctions and abnormalities. This is linked to inflammation, pain, and blood vessel abnormalities. Some research findings listed on this link - http://phoenixrising.me/archives/13083 and at this link http://mastcellmaster.com/research.php
- Tryptase, histamine, heparin blood
- Eosinophilia, basophilia, monocytosis activity
- Serum chromagranin A
- Serum and urinary leukotriene and prostaglandin isoforms
- Urine methylhistamine after exercise
- Also test for abnormal levels of neuropeptide Y as this directly affects mast cell functions
- NAET therapy is highly effective for identifying and removing allergies
- Toxic causes of allergies